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Capturing live tumor cells in the blood

Tumor cells circulating within a patient's bloodstream can carry cancer from a primary tumor site to distant sites of the body, spreading the disease. Now a team of researchers in China has developed...

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Role of protein vinculin in cell movement

Researchers at the University of North Carolina and the National Institutes for Health have defined the role of the protein vinculin in enabling cell movement. In a paper published in the Journal of...

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A protein provides stress relief

Freiburg researchers have shown a new mechanism via which cells defend themselves against stress. Dr. Kathrin Thedieck and Birgit Holzwarth from the Institute of Biology III and the Cluster of...

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New tool enhances the search for genetic mutations

Concealed within the vastness of the human genome, (comprised of some 3 billion base pairs), mutations are commonplace. While the majority of these appear to have neutral effect on human health, many...

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Nanoparticles to deliver vaccines to lungs

Many viruses and bacteria infect humans through mucosal surfaces, such as those in the lungs, gastrointestinal tract and reproductive tract. To help fight these pathogens, scientists are working on...

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Potential new drug for inherited cancer

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a new drug candidate for an inherited form of cancer with no known cure. The new study showed the drug...

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Does good cholesterol increase breast cancer risk?

High levels of high density lipoprotein (HDL), also known as the "good cholesterol," are thought to protect against heart disease. However, what’s good for one disease may not be good for another....

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Cancer Genome Atlas exposes more secrets of lethal brain tumor

When The Cancer Genome Atlas launched its massively collaborative approach to organ-by-organ genomic analysis of cancers, the brain had both the benefit, and the challenge, of going first. TCGA ganged...

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Red wine could help treat multiple types of cancer

A recent study by a University of Missouri researcher shows that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment. This...

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Safe delivery system for tricky yet potent anti-cancer cancer compound

Researchers at the University of California, San Diego School of Medicine have discovered a way to effectively deliver staurosporine (STS), a powerful anti-cancer compound that has vexed researchers...

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Immune system monitoring improved

MHC tetramers are important diagnostic reagents that are used by doctors and scientists to follow a patient's immune response against a virus or a tumor. Their application has so far been limited...

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Stealth nanoparticles lower drug-resistant tumors' defenses

Some of the most dangerous cancers are those that can outmaneuver the very drugs designed to defeat them, but researchers are now reporting a new Trojan-horse approach. In a preliminary study in the...

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Decision circuit of cancer metastasis

Cancer researchers from Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study...

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Are you carrying adrenal Cushing's syndrome without knowing it?

Genetic research that will be published in the New England Journal of Medicine suggests to Dr. André Lacroix, professor at the University of Montreal, that clinicians' understanding and treatment of a...

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Pills of the future: Nanoparticles

Drugs delivered by nanoparticles hold promise for targeted treatment of many diseases, including cancer. However, the particles have to be injected into patients, which has limited their usefulness so...

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A rescuer for vital tumor-suppressor

A protector for PTEN, a tumor-thwarting protein often missing in cancer cells, has emerged from research led by scientists at The University of Texas MD Anderson Cancer Center published online at...

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And the winner is …. cancer research

The three winners of the first Roche Pharma Research & Development (pRED) Oncology Awards in the field of ‘Novel Highly tumour-selective Membrane Targets for Antibody-based Cancer Therapy’ have...

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Novel noninvasive therapy prevents breast cancer formation

A novel breast-cancer therapy that partially reverses the cancerous state in cultured breast tumor cells and prevents cancer development in mice, could one day provide a new way to treat early stages...

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Weighing particles at the attogram scale

MIT engineers have devised a way to measure the mass of particles with a resolution better than an attogram — one millionth of a trillionth of a gram. Weighing these tiny particles, including both...

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DNA-built nanostructures safely target, image cancer tumors

A team of researchers at the University of Toronto has discovered a method of assembling "building blocks" of gold nanoparticles as the vehicle to deliver cancer medications or cancer-identifying...

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Finding a target for tumor suppression

One of the hopes for victory against cancer hinges on naturally-occurring proteins whose job is to make their host cell die. Since their natural role is to stop unhealthy cell proliferation, the idea...

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New application of physics tools used in biology

A Lawrence Livermore National Laboratory physicist and his colleagues have found a new application for the tools and mathematics typically used in physics to help solve problems in biology....

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Twin sisters provides clues for battling aggressive cancers

Analyzing the genomes of twin 3-year-old sisters – one healthy and one with aggressive leukemia – led an international team of researchers to identify a novel molecular target that could become a way...

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A new postal code for cancer

Scientists have discovered that a polymer can provide a key to get into tumors: Prof. Prasad Shastri, Director of the Institute of Macromolecular Chemistry and core member of the cluster of excellence...

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Role of infliximab in treating Kawasaki disease

Kawasaki Disease (KD) is a severe childhood disease that many parents, even some doctors, mistake for an inconsequential viral infection. If not diagnosed or treated in time, it can lead to...

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Beta-catenin alters T cells in lasting and harmful ways

Activation of beta-catenin, the primary mediator of the ubiquitous Wnt signaling pathway, alters the immune system in lasting and harmful ways, a team of Chicago-based researchers demonstrate in the...

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Catching the early spread of breast cancer

When cancer spreads from one part of the body to another, it becomes even more deadly. It moves with stealth and can go undetected for months or years. But a new technology that uses "nano-flares" has...

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How brain tumors develop from stem cells

What causes cancer? This is still one of the most burning questions today. Cancer stem cells are increasingly to be found in the spotlight of research. Researchers from the Biozentrum of the...

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What keeps tumor cells in place

Researchers at the University of Freiburg have found switches that colorectal cancer cells use to migrate away from the primary tumor site and to invade neighboring tissue. This migration is the first...

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The human 'hairless' gene identified

It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose...

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Protein key to cell motility

"Cell movement is the basic recipe of life, and all cells have the capacity to move," says Roberto Dominguez, PhD, professor of Physiology at the Perelman School of Medicine, University of...

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Kill resistant tumor cells

Researchers from the University of Pittsburgh Cancer Institute (UPCI), a partner with UPMC CancerCenter, have found that an agent that inhibits mitochondrial division can overcome tumor cell...

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Nano shake-up

Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge. Nanotechnology has...

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Emerging psoriasis therapies go head-to-head with marketed drugs

The market for moderate-to-severe plaque psoriasis therapeutics is becoming increasingly competitive with the imminent arrival of three promising new drug classes: interleukin-17(IL-17) inhibitors, a...

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Two-lock box delivers cancer therapy

Rice University scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo. The Rice lab of bioengineer Junghae Suh has...

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Male infertility: It's all about the package

Infertility is generally thought of as a woman's problem. In fact, more than 3 million men across America also experience it. Today, researchers from Cold Spring Harbor Laboratory (CSHL) describe a...

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Merck Serono Awards €1 Million to the Winners of the first Grant for Oncology...

Merck Serono, the biopharmaceutical division of Merck, announced the winners of the first Grant for Oncology Innovation (GOI), who will receive grants totaling €1 million. The 2014 winners were...

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Study identifying cell of origin for large, disfiguring nerve tumors lays...

UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new...

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Oncoethix starts Phase 1b Trials of OTX015 in the Treatment of Advanced Solid...

Oncoethix announced that the first patient has been enrolled in an international, open-label, non-randomized, multicenter Phase 1b trial of OTX015 in advanced solid tumors.  The trial will be...

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Crown Bioscience Acquires Molecular Response’s Patient Derived Xenograft...

Crown Bioscience, Inc. has announced the acquisition of Molecular Response’s PDX models and PDX service operations. The acquisition reinforces Crown’s on-going strategy to be the leading global...

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Higher Tumor Rates by Exposure to Electromagnetic Fields

Electromagnetic fields stimulate the growth of tumors in mice. This is the result of a new study by researchers from Jacobs University in Bremen, Germany, which was commissioned by the Federal Office...

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Watching a tumour grow in real-time

The ability to visualize and characterize the composition of a tumour in detail during its development can provide valuable insights in order to target appropriate therapeutics. Researchers from the...

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Research team identifies structure of tumor-suppressing protein

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN....

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Turncoat protein regulates sensitivity of breast cancer cells to drug

A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common...

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Chemotherapy can cause tumor evolution

Russian scientists have found that neoadjuvant chemotherapy in patients with breast cancer can stimulate evolution of the tumor. The research was conducted by Nicholay Litvyakov, D.Sc. at Cancer...

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From tamoxifen to dendrogenin A: Discovery of a mammalian tumor suppressor...

Researchers from the Cancer Research Center of Toulouse have conducted the first comprehensive review on dendrogenin A (DDA). DDA is a steroidal alkaloid arising from cholesterol and histamine...

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Novel gene variants identified in male breast cancer

Male breast cancer (MBC) is a very rare tumor type, occurring in just 1% of all breast cancer cases, and the underlying genetic causes and treatment of MBC is not well understood. In a paper...

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Model of tumor spreading may help doctors pinpoint best treatment

Advances in personalized medicine allow doctors to select the most promising drugs for certain types of malignant tumors. But what if before initiating treatment, they could go a step further and use...

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Life-preserver microbubbles float tumor cells for analysis

A University of Colorado Cancer Center study presented at the American Association for Cancer Research Annual Meeting 2016 demonstrates the use of gas microbubbles to selectively attach to and float...

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Successful laboratory test of photoswitchable anti-tumor agent

Photoswitchable agents might reduce side effects of a chemotherapy. So far, photodynamic therapies have been dependent on oxygen in the tissue. But hardly any oxygen exists in malignant, rapidly...

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